Receptor response
GLP1R · 4 variants
How strongly your GLP-1 receptors are likely to respond to signaling — the best-studied genetic contributor to response.
GLP-1 response genetics
Know more before your next GLP-1 decision.
A single at-home cheek swab reads genetic markers associated with GLP-1 response and tolerability — and gives you a plain-language report to bring to your provider.
- CLIA & CAP certified lab
- HIPAA secure
- Clinician reviewed
- GLP1R
- CNR1
- CTRB1
- genetic variants across 3 genes
- 6
- to results once your sample reaches the lab
- 2–3 weeks
- cheek swab — no needles, no fasting
- 1
- your DNA does not change
- Lifetime
Who it is for
TRU-1 is for you if you…
- Are considering a GLP-1 such as semaglutide or tirzepatide and want more context first
- Are already on a GLP-1 and not seeing the results you expected
- Have struggled with nausea or GI side effects on a GLP-1
- Want a shareable report for your next provider conversation
- Prefer a simple at-home swab over a lab visit
What TRU-1 reads
Three biological questions, one plain-language answer
GLP-1 response is not a single switch. TRU-1 looks at the variants most often linked to why two people on the same dose can have very different outcomes.
Appetite & tolerability signals
CNR1
A receptor involved in appetite regulation that has been associated with differences in response and GI tolerability.
Metabolic context
CTRB1
An emerging marker associated with differences in GLP-1 response, reported alongside the strength of its evidence.
Your response profile
How the markers combine into a likelihood tier, a tolerability watch-list and talking points written for your prescriber.
How it works
Order online, swab at home, share the report
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Order your kit
Checkout takes a minute. Your kit ships in discreet packaging with prepaid return postage.
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Swab your cheek
Sixty seconds. No fasting, no needles, no lab appointment.
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Lab analysis
Genotyped in a CLIA & CAP certified lab and reviewed before release.
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Read and share your report
Results land in your secure account with a PDF you can hand to your provider.
Inside the report
Written for a decision, not a database
- A response likelihood tier — likely strong, moderate or limited — with the evidence behind it.
- A tolerability watch-list ranked by your own variants, so titration conversations start informed.
- Provider talking points in clinical language, on one page.
- Every marker with references, stored securely for as long as you want it.
- A Genie walkthrough of what your GLP-1 profile may suggest, plus questions for your next appointment.
Genie
Walk through your GLP-1 profile before the next appointment.
Genie reads your TRU-1 markers and talks them through in everyday words: what the response tier may suggest, what to watch for on tolerability, and the questions worth putting in front of your clinician.
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Insights unique to you
Your GLP1R, CNR1 and CTRB1 results — not a pamphlet about GLP-1s in general. Genie only speaks from the panel you have resulted.
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Plain-language walkthrough
What Enhanced Benefit or a more cautious tier may mean for response and side effects, without promising an outcome.
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Questions for your clinician
Genie helps you walk into the visit with talking points: titration, tolerability, and how genetics sits alongside your history and goals.
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Why your score moved
Ask why your Blueprint Score changed, which test is worth doing next, or how TRU-1 sits next to Lumyn or PGX.
Genie is educational support, not a diagnosis or a prescription. Prescribing decisions stay with your licensed provider.
Test details
TRU-1 at a glance
- Sample type
- Buccal (cheek) swab
- Turnaround
- 2–3 weeks after the lab receives your sample
- Markers
- 6 variants across GLP1R, CNR1 and CTRB1
- Lab
- CLIA & CAP certified
- Report
- Secure online account + downloadable PDF
Questions
TRU-1 questions, answered
No. TRU-1 is a genetic test you can order yourself. GLP-1 medications themselves do require a prescription from a licensed provider — your report is designed to help guide that conversation.
No. Many people test mid-treatment to add context to a plateau or persistent side effects. Your DNA does not change, so the result is just as useful now as before you started.
No. TRU-1 informs the conversation; it does not predict an individual outcome or replace your clinician's judgement. Prescribing decisions stay with your provider, and the report is written for them to read.
Yes. Samples are processed in a CLIA & CAP certified lab, your data is stored HIPAA-securely, and we never sell or license genetic data. You can request deletion at any time.
TRU-1 is an elective test and is typically not covered by insurance. Many people find it worthwhile to avoid months of trial and error with an expensive medication.
TRU-1 answers one question: how you may respond to GLP-1 therapy. Blue Genes Clinical PGx is a provider-ordered panel covering dozens of medication classes. If you are on several medications, PGX may be the better place to start.
Genie can walk you through your GLP-1 response profile in plain language, help you prepare questions for your clinician, and explain how the result sits alongside your history and goals. It does not prescribe or pick a drug for you.
Compare
Which test is right for you?
| Feature | TRU-1 GLP-1 response genetics | Lumyn Genetic wellness panel | PULS At-home blood test | Blue Genes Clinical PGx Pharmacogenomic panel · provider-ordered |
|---|---|---|---|---|
| Best for | Deciding on, or troubleshooting, a GLP-1 | Everyday nutrition, energy and sleep | A broader view of your overall health | Medication safety across many prescriptions |
| Sample | Cheek swab | Cheek swab | At-home blood collection | Cheek swab |
| Turnaround | 2–3 weeks | 2–3 weeks | 48–72 hrs | 7–10 days |
| What it measures | 6 variants across 3 genes | 39 genes, 49 variants | Multiple blood biomarkers across major areas of health | Medication-response genes, dozens of drug classes |
| How to order | Order online | Order online | Order online | Provider-ordered |
| Price |
$249
|
$299 | Starting at $100 | Provider-ordered |
| Action | Order | Order | Order | Register to get started |
Stop guessing. Start knowing.
One swab, one clear report, more context for the conversation that shapes your next twelve months.